Paediatric MOGAD encephalitis can result in poor long term outcome (mRS>2) with progression to leukodystrophy or cortical atrophy. 2 Indeed, MOG antibody accounts for the majority of ADEM and non-ADEM autoimmune encephalitis (AE) presentations in children 8,10 and is associated with a higher risk of relapse than MOG antibody negative disease. 7Īcute disseminated encephalomyelitis (ADEM) is the most common initial presentation in children under 9 years. 8,9 Residual paraparesis is less common than in AQP4-NMOSD. Early bowel, bladder and sexual dysfunction, reflecting central cord and conus involvement, increases suspicion for MOGAD. Both longitudinally extensive and short segment TM are observed. 2 TM in MOGAD may mimic that seen in AQP4-NMOSD and MS. It is the second most frequent presentation in adults and older children. Transverse myelitis (TM) may occur in isolation or with ON to mimic Devic’s disease. 6,8 Symptom resolution is anticipated but up to 20% of patients may have permanent visual impairment. 7 Papillitis is frequently identified in MOGAD, consistent with the anterior visual pathway involvement often seen in this condition. The rate of simultaneous or sequential, bilateral ON is higher than seen in MS or AQP4-NMOSD. Optic neuritis (ON) is the most frequent presentation in adults and children over 9 years. 2,7 A prodromal infection is reported in up to 47% in some studies. The MOGAD clinical phenotype is diverse and varies with age. There are limited reports of association with other autoimmune diseases but fewer than seen with AQP4-NMOSD. There is insufficient data to establish ethnicity or latitude as risk factors. Unlike AQP4-NMOSD and MS, a female preponderance is not evident. 5 Existing cohort studies are small and frequently combine paediatric and adult samples. A recent comparative survey has shown MOGAD is at least twice as common as AQP4-NMOSD. The prevalence of MOGAD is not well established. In MS, lesions are predominantly leukocortical, have a CD8 T-cell infiltrate with chronic radial expansion, whilst in MOGAD plaques are intracortical, associated with a CD4 T-cell inflammatory infiltrate and show preserved AQP4 expression. 2 Pathologically in the brain MOGAD, like MS, shows white matter demyelination characterised by perivenous inflammatory aggregates. MOGAD-like pathology has been induced by encephalitic viruses in transgenic mice expressing MOG antibody. 3 How it bypasses the blood-brain barrier remains unknown. It is likely to be peripherally produced, frequently of the IgG1 isotype, and demonstrates reactivity to an extracellular antigenic region around Proline42 in a large subset of patients. 2 MOG antibody is encephalitogenic in vitro. While its biological role is poorly understood, its association with CNS disease is increasingly apparent. MOG is expressed on the outer sheath of myelin by mammalian CNS oligodendrocytes, prominently exposed to the extracellular space. 1 Recognition of this distinction promotes targeted therapy and prospective research. Its clinical presentation, investigation, management and prognostic considerations distinguish it from multiple sclerosis (MS) and AQP4 antibody associated neuromyelitis optica spectrum disorder (AQP4-NMOSD). Myelin Oligodendrocyte Glycoprotein (MOG) antibody associated disorder (MOGAD) is a unique demyelinating pathology affecting adult and paediatric populations. Here we summarise what is currently known of the pathophysiology, clinical presentation and management of MOGAD. A number of other rare presentations have also been described. Distinct patterns of MOG antibody associated disorder (MOGAD) include acute disseminated encephalomyelitis (ADEM) in children and overlap with neuromyelitis optica spectrum disorders (including classical Devic’s presentations), optic neuritis, transverse myelitis, and focal encephalitis in both children and adults. The advent of more precise live cell-based assays for antibody detection in serum and cerebrospinal fluid (CSF) has greatly refined the clinical phenrotype of demyelinating diseases associated with MOG antibodies. The existence of antibodies to myelin oligodendrocyte glycoprotein (MOG) in some patients with CNS demyelinating disease has been recognised for 30 years, but their clinical utility as biomarkers, and potential pathogenicity in humans has only become apparent in the past 15 years.
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one of the biggest natural nuggets ever discovered was found in the Urals in 1842 weighing approx.We know the following types of gold deposits Many gold nuggets are so called placer gold nuggets and can be found washing gravel, stones and sand to get to the nuggets. If the nugget was melted out of gold jewelry, the purity can be in the range of 40% to 55% pure gold or higher but if the nugget was melted out of gold plated electronic parts like plugs or panel pieces the purity can be less than 10% pure gold. I'm not sure I'm comfortable with you being out here by yourself. The purity can vary much because it depends on the melted materials if a nugget contains much or less pure gold. real soon and I think you have plans to move out here. Usually, artificial gold nuggets are created by goldsmiths to collect gold-remains left from their work. Humanly created gold nuggets can sell for the current gold value because they are not special or worth to collect. Please also check our value-examples further down this page to get an idea how much bigger-sized gold nuggets are worth. A natural 1 gram gold nugget containing 95% pure gold is worth $55.04, today. 95% pure gold while Australian mined nuggets can contain up to 99% pure gold. North American mined natural nuggets usually contain approx. Most natural gold nuggets appear either as a pure nugget or in combination with a host rock like quartz. Small natural gold nuggets, mined from Alaska to Australia, are also “only” worth the gold price because they are not either really rare or exceptional. While bigger natural gold nuggets are reflecting a value higher than the gold price, humanly created gold nuggets are always “only” worth the current gold price. So, enjoy Gold, whether in a piece of jewelry, coins, or as a natural gold nugget or gold quartz specimen.We have to differ between natural gold nuggets and artificial, human created, gold nuggets to talk about how much they are worth. The karat value, or fineness of the gold remains the same as with yellow gold, as just the color differs because of the other metals used for the alloys. Pink or rose gold is an alloy of yellow gold and copper, while White Gold is alloyed with Nickle, Zinc, Palladium or Platinum. Pure gold is stated as 24kt, 18kt gold is 75% gold, 14kt gold is 58% gold and so on. The percentage of pure gold in the alloy is stated in karats, abbreviated as Kt or K. Gold is normally alloyed with silver or copper to make a stronger mix of metals. Our online collection features unique locally fashioned. Gold, in its pure state, is so soft that it is normally mixed with another metal before being used in jewelry. NGNJ is Western Australias premier source of high purity, ethically sourced natural gold nuggets. Fortunately, now the appreciation of the rarity and uniqueness of natural Gold have caused Gold nuggets to be treasured in their natural form for fine jewelry and for collections. Until recently, gold nuggets themselves held no intrinsic value and were assayed strictly for gold value. Natural Gold nuggets have become even rarer since almost all gold nuggets found prior to 1990 have been melted. A Gold nugget is usually 70 to 95 percent gold, and the remainder mostly silver. The reasons for valuing Gold have not changed a great deal. While the gold-plating may be real gold, the gold composition is not enough. In early times, gold symbolized wealth, power and strength. Gold also formed the basis of many monetary systems. The exquisite color and supurb workability made Gold highly sought after for decorative items and ancient jewelry. The first gold found occurred naturally on the surface of the earth or as nuggets in rivers and streams. The precious metal “Gold” has excited humans since the earliest dawn of time. We'll add a 1/2lb of "Sharon's Homemade Chocolate Pecan Fudge"Īdd-on #3 "Orange Blossom Honey" We'll add a Full 1lb. 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He quietly became one of the most sought-after executives in the industry even serving as President of A&R at Geffen 2010-2012.Ģ012 saw Hip Hop Since 1978 evolve into The Blueprint Group. He went on to spearhead A&R for T.I., Plies, Maino, and many more at Atlantic, while working on projects for Nicki Minaj, Lil Wayne, and others for Hip Hop Since 1978. In 2004, he was named Vice President of A&R at Atlantic Records and simultaneously entered the fold at the full-service management and production company Hip Hop Since 1978founded by Gee Roberson and Kyambo “Hip-Hop” Joshua. With Spalding Entertainment’s 11 acts, including Jason Aldean, Darius Rucker, Reba McEntire, Rascal Flatts and Brooks & Dunn, Maverick becomes one of the biggest management groups in Nashville. FOLLOWTHEBLUEPRINT Founded in 2008, Blueprint Group, Inc. 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Maverick Partners With Big Loud Management, Expands Nashville Footprint: Exclusive. He noted that the average number of members per gym in Singapore is "between 800 and 1,200". While this number may seem mind-boggling, Thomas explained how the gym can recoup back the amount in a relatively short space of time.Īs prices vary from location to location, he used $100 a month as the average cost of an Anytime Fitness monthly membership. It's all about the attractive returns, he Fitness as his case study, Thomas started by providing a breakdown of the initial investment required.Īccording to Thomas, Anytime Fitness Singapore has an initial franchise fee of $90,000.įor reference sake, Anytime Fitness' franchise fees in the US include a one-time $42,500 (S$55,700) payment and an ongoing $699 monthly payment.ĪsiaOne reached out to Anytime Fitness Singapore, but they declined to comment on the given figures provided in the article.Īdd in other costs such as construction, equipment deposit and real estate costs, the total amount came up to a whopping $410,000. On Wednesday (Jan 25), he shared a 108-second long clip on his TikTok account Steadycompound about why 24/7 gyms have been "spawning everywhere". It might sound a little too good to be true, but Thomas went on to back his claims with numbers. The Singaporean went as far as saying that gym franchise owners could potentially break even in six and a half months due to a monthly profit of over $62,000. If you've ever had ideas of starting a business, becoming a gym franchise owner could be something that'll work out.īad pun aside, there might be some truth to the statement - according to Thomas Chua, founder of stock research service Steady Compounding, at least. A scarcely glimpsed figure in a firefight casts doubt on a decades-long tale of grief. A living-room dance turns into a fight and back again with every motion edged in menace. there is deft, detailed filmmaking at work too. Nodding to Cronenberg ( Crash) and anime and Claire Denis (there’s Beau Travail in the many men-with-men dancing scenes, and there’s a little High Life ) fuckbox in the car-intercourse scenes) and Holy Motors and Nicolas Winding Refn (if he had the stones), Titane is bold in its reference points, no-holds-barred in its approach to some of the hottest-button issues of the day, and brash – and often very funny – in its deliciously grisly and inventive image-making. Ducournau’s filmmaking is as pure as her themes are profane: to add insult to the very many injuries inflicted throughout, Titane is gorgeous to look at, to listen to, to obsess over, and fetishize. But while God has almost certainly forsaken this movie, He wouldn’t have been much needed around it anyway. is roughly seven horror movies plus one bizarrely tender parent-child romance soldered into one machine and painted all over with flames: it’s so replete with startling ideas, suggestive ellipses, transgressive reversals and preposterous propositions that it ought to be a godforsaken mess. Alexia, binding down her breasts and her burgeoning, unwanted pregnancy sired by a Cadillac, becomes an improbable Adrien. - Sandra Reid Prone to doubts about his masculinity, he’s also grieving for Adrien, a teenage son who disappeared years earlier. When a murder goes awry, Alexia must go on the run, and her path leads her to a fire station populated with hunky young firemen and their steroid-consuming aging chief (a stunning turn from Vincent Lindon). Julia Ducournau brazenly smashes the mould with this twisty tale about Alexia (a thoroughly committed performance from Agathe Rousselle), an erotic dancer with a peculiar penchant for muscle cars, who also happens to be a serial killer when the random urge takes her, or people pests provoke retaliation. It was probably also the first time that a so-called “genre” film, especially one that ups the ante to such a degree in “horror” movie stakes, scooped the top award. Wild, outrageous, unruly, hallucinatory, body/machine-modification-run-amok, masterful, cartoonish, genre- and gender-bending Titane was awarded the 2021 Palme d’Or, only the second time in Cannes Film Festival history that a woman director has received the accolade (28 years after Jane Campion’s The Piano). We are thrilled to close the Festival with the shock 2021 Palme d’Or winner. After all, you have to believe in your application before anyone else will. For that reason, it’s a good idea to take time to reflect on and celebrate what you’ve done before, during and after the resume-writing process. Which aspects of your educational and professional life you choose to emphasize and the language you use to describe the work you’ve done can tell admissions officers a lot about your attitude toward your own accomplishments. Perhaps more than anything else, a resume conveys how you understand your own achievements. It never hurts to have another reader take a look at your work and make sure it’s written in a clean, clear voice. If you are not secure in your proofreading skills, ask a friend or colleague to read it through. A degree from “Harvfard” isn’t going to impress anyone. That means customizing it for each application, editing it carefully to make sure it presents your accomplishments in the best possible light for each particular program, and proofreading rigorously. This document is a summary of your major accomplishments over the course of several years, and you should take pride in it. Regardless of what your specific accomplishments are, your resume should present them in a careful and polished manner. For example, writing in the active voice is good because it is efficient and conveys a sense of energy, but buzzwords like “dynamic” and “detail-oriented” will only tip off admissions officers to the fact that you read an article about how to write a resume. The Internet is full of clichés about writing resumes, and you should be careful about which tips you use as you update your resume. Think about the language you use, and choose words carefully to convey as much as you can about your accomplishments in the minimal amount of space a resume provides. Extracurricular activities are another way you can let admissions officers know about your personal passions and even your leadership experience.Ī resume is no place to waste words. If you’re a professional looking to change fields, volunteer work or internships can also help to bridge the gap between your current profession and your desired field. If you’re applying to graduate school straight out of undergrad, you may not have a lot of professional experience, but internships or volunteer work can tell admissions officers about your interests while demonstrating that you’re willing to work hard for reasons other than immediate material rewards. In addition to identifying your alma mater, degree earned and year of graduation, detail some of the more relevant classes you took and any academic honors you earned.ģ. You should also go into greater detail about your education than you would on your average professional resume. The two documents also tend to be formatted differently (for instance, a resume is usually one page while a CV is two pages), although neither document has a single standard format.īecause you’re applying for admission to an academic program, your resume or CV should emphasize academic accomplishments over professional accomplishments. Both documents present a short history of your accomplishments, but a resume emphasizes professional accomplishments, while a CV emphasizes academic accomplishments. For instance, Master of Arts in Teaching (MAT) or Master of Education (ME) programs can ask for either a resume or a CV, while MBA programs will ask for a resume. These five tips will help you prepare the perfect resume for applying to a master’s program:ĭepending on what type of master’s program you’re applying to, you may be asked to prepare either a resume or a CV. The rules for writing a resume or curriculum vitae (CV) for graduate school are a little different than they are for the ordinary job hunt, but the end goal is still the same: you want to make it is clear that your particular qualifications make you a good fit for this opportunity. Students and Gender Identity Guide for Schools. Toolkit for Digitally Literate Teachers.Doctor of Education in Educational Leadership online.Doctor of Education in Organizational Change and Leadership online expand_more.Master of Education in Enrollment Management and Policy online.
But to find the most comfortable fit for you – we need to assess your feet in person. To that, Owen our Pedorthisthas hand-picked a collection of men’s shoes that help with conditions like Plantar Fasciitis, Achilles Tendonitis, Bunions, Diabetic Foot, Corns, Calluses, and more. We also understand the common foot problems and foot pain faced by men in Singapore. To show how serious we are – all footwear purchased from Footkaki receives 6 months warranty & fitting modifications support. That’s our guarantee – if you get any footwear from Footkaki – we jolly well make sure that they fit comfortably. We only carry footwear that is comfortable, and built to last you a good while. Ask us about the stories and features behind each pair, and we’ll be glad to demonstrate the amount of quality and work put in to make a pair of comfortable and healthy men’s shoes, sandals, or slippers. Our selections come with good structural construction to support healthy foot biomechanics, or to accommodate any custom orthotics, insoles, or shoe inserts made by a qualified Podiatrist. In good old professional shoe fitting style, we also make sure that the men’s footwear we carry are all made with genuine high-quality materials and orthopaedic comfort features. Savvy shoppers will definitely spot that our sandals are priced more ethically than some shops (feel free to compare and let us know). The sandals we carry are not cheap , but we do our best to give you the most affordable, value-for-money, and comfortable healthy footwear options. That’s why we price our sandals at honest margins that are as close as possible to retail prices in their home countries, with a little extra to cover additional freight costs, import taxes, and annoying trade war fluctuations (thanks, Donald Trump). We want to be honest. We started our little shop to make healthy footwear affordable to people who need them. From traditional cork sandals to orthotic-friendly slippers with removable footbeds, we will professionally fit you for a comfortable pair that best fits your needs.Īlthough not listed here, diabetic-friendly men’s shoes from Dr Comfort® are also available on special order (yes, feel free to ask your Podiatrist about us). Great for gentlemen going for a continental style without sacrificing comfort. We import them directly from Italy, where they are made with high-quality natural materials and European craftsmanship. You will also find comfortable orthopaedic sandals by Grünland®. Perfect for avid runners, sportsmen, NSFs, regulars, F&B staff, and other hardworking fellas who need recovery sandals at a fair price. They’re proven to relieve and rehabilitate painful foot conditions like heel, forefoot, and ankle pain. We are proud to carry Singapore’s widest range of supportive flip flops and slippers by Spenco® Footwear – all built with arch support and accepted by the American Podiatric Medical Association (APMA). There’s something for every guy who need something comfortable to slip in while letting your feet breathe. Take a look and see why the Healthy Feet Store is the fastest growing orthopedic shoe retailer on the internet.Are you looking for Flip Flops, Sandals, or Slippers with Arch Support?Īt Footkaki, we’ve assembled a solid collection of men’s orthopaedic sandals and slippers to fit most feet types and foot conditions in Singapore. Give your feet a break by browsing our impressive selection of men's slippers today and shopping right from the comfort of your own home. Our premium-quality orthopedic slippers for men are available at our everyday low prices and our convenient shipping options allow you to have your selections sent right to your door in very little time. In addition to a wide selection of sizes and styles, we also carry men's house shoes with arch support from some of the leading brands in the industry including Cloud Nine Sheepskin, Old Friend, and Comfortrite, and Acorn. We also offer EASY returns & FREE exchanges to take the stress out of shopping for shoes online. Not sure what size to order? Simply consult the sizing guide attached to individual products for item-specific sizing. To ensure the right fit, we carry a wide variety of sizes and styles to choose from. Your feet are unique and you need slippers that fit properly. Unlike drugstore slippers, we don't believe that one-size-fits-all. Here, rust, grime, and other debris can block the radiator’s tubes and distort the smooth operation of the thermostat and water pump. In addition, when a radiator is not flushed regularly and supplied with appropriate coolant, it gathers impurities. Like other metal components, the radiator can rust with time. When the trapped air reaches the radiator intake or coolant’s valve, it generates bubbling. When the water pump is bad, air enters the pump intake. The water pump helps circulate antifreeze or coolant through the radiator’s cooling tubes, where it cools and flows to the engine components through the engine paths and pipes. The hose that connects the radiator to the coolant reservoir must be leak-free and tight at all times if the radiator hose is bad or worn, air sips into the hose and causes the coolant tank to boil. When the heater’s valve is faulty, or the heater’s hose connection is loose, the air slips into the cooling system and results in coolant boiling in the reservoir. The heater control works to keep the passenger compartment hot by allowing hot coolant to enter the heater’s core. When the head gasket is bad, combustion gases from any cylinder slip into the water jacket, then send air through the cylinder head into the cooling system.Īn easy way to know the bubbling is due to a leaky gasket is that bubbling occurs immediately after starting the engine. Leaky or blown head gasketĪ worn or blown head gasket is a prevalent cause of bubbles in the coolant tank. And thus, it causes a bubbling effect in the coolant reservoir or radiator since there is an uncontrolled airflow. When the thermostat is faulty, it doesn’t open and closes at the appropriate time. Then remain close for the engine to heat coolant to start the car. It should open to let out the hot coolant from the engine into the radiator to cool. Here, the thermostat must open and close at a specific time. The thermostat regulates the flow of coolant in and out of the radiator. When this cap is faulty or replaced with a non-compatible one, it allows air into the cooling system, causing the coolant reservoir to boiling.Īn easy way to know bubbling is due to a bad radiator cap is that you will see bubbles in the coolant reservoir after driving for a long. The radiator cap works as a pressure seal to keep pressure in the cooling system high while letting coolant flow into the expansion tank. As you drive the car and it heats up, the air pockets expand and are pushed into the coolant reservoir. As the engine cools down, the expanded air pockets contract hence, coolant is sucked from the reservoir to replace air. When coolant is flushed and refilled, air pockets are trapped in the cooling system. In other cases, the air in the cooling system could mean there is some faulty component that needs to be addressed. Because some actions will naturally cause air to sip into the cooling system. The air pocket blocks the flow of liquid, which leads to a rise in temperature, causing coolant to boil inside the reservoir.īubbles in reservoirs could be severe, and sometimes, it could be something to not worry about. When air finds its way into this closed system, it forms air pockets. How? Many vehicle cooling systems are pressurized and use a sealed hose system that allows coolant flow around the engine. The air causes bubbles in the coolant reservoir. What causes bubbles in the coolant reservoir? While some may not need you to worry, others will require you to take immediate action. Bubbles in a coolant reservoir could suffice for different reasons. However, at a point coolant reservoir may start boiling, and you may wonder why. This coolant is stored in a rubber tank called the coolant reservoir from here it dispatches coolant to engine components. This system relies on a close network of pipes that carries coolant to the engine. However, most vehicles utilize the liquid cooling system. Automobiles depend on either a liquid or air cooling system to keep the engine running effectively. He decides to blackmail his former partners and emails them a threat: He has 90 gigabytes of incriminating emails and data on illegal investments and money transfers unless he gets his two mill, he’ll leak it to the press. He wants the $2 million promised to him in his severance agreement that he never received, money he feels is rightfully his. His ex-partners cut him out of a business that’s suddenly, mysteriously, worth more than a billion dollars. A son of Spaniards who’d emigrated to Switzerland, Justo is a former Swiss banker, but more importantly, he’s a man with a world-shaking grudge. The Inside Story of How ‘Wild Wild West’ Spun Out of Controlįive months later, halfway around the world in Thailand, a man named Xavier Justo plots revenge against his former business partners, men who are also partnered with Jho Low. This is the beginning of the end, but no one knows it yet. Pharrell has to step in and calm the situation down. Nonetheless, it’s obviously a tense moment - a non-black man telling a black man that he owns him. The Malaysian financial wunderkind is drunkenly referring to the fact that he now co-owns EMI Group Limited, a music publishing company, and thus, Busta’s rhymes. Low shouts at Busta, “Yo! I own you! You’re my bitch!” At one point in his recording session, rapper Busta Rhymes and super-producer Pharrell Williams show up. The ballad the 30-year-old sings is called “Void of a Legend.” The man calls himself Jho Low. Ensconced in a Chelsea studio bubbling with celebrities and champagne, an international man of mystery records his vanity music project. |
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